TY - JOUR
AU - Hruby, Victor
AB - Using the method of conformational constraint, we have designed and synthesized analogues of deltorphin I containing each of the four stereoisomers of the unusual amphiphilic amino acid β-hydroxyphenylalanine in position 3. The potency and selectivity of these analogues were evaluated by radioreceptor binding assays and by bioassay in MVD and GPI. The results show that introducing a hydrophilic group into the β-carbon of Phe3 decreases the affinity and biological activity of δ-opioid receptors, which strongly depend on the chirality of the α-carbon, but not on that of the β-carbon.
TI - Amino acids with amphiphilic side chains: Deltorphin analogues with Phe3 replaced by all β-hydroxyphenylalanine diastereoisomers
JF - International Journal of Peptide Research and Therapeutics
DO - 10.1007/BF00119153
DA - 2004-05-17
UR - https://www.deepdyve.com/lp/springer-journals/amino-acids-with-amphiphilic-side-chains-deltorphin-analogues-with-ZxpBy2VgRO
SP - 203
EP - 205
VL - 2
IS - 4
DP - DeepDyve
ER -