TY - JOUR
AU - Fineberg, Harvey, V.
AB - Abstract In August 1991 the Institute of Medicine released a report entitled “Adverse Effects of Pertussis and Rubella Vaccines” that examined, among other relations, the relation between immunization with the RA 27/3 rubella vaccine strain and chronic arthritis. The committee spent 20 months reviewing a wide range of information sources including case series and individual case reports published in peer-reviewed journals and reported by vaccine manufacturers; unpublished case reports from physicians, parents, and other concerned persons; epidemiological studies; and laboratory studies. There were no animal studies available. The committee found that the evidence is consistent with a causal relation between the RA 27/3 rubella vaccine strain and chronic arthritis in adult women, although the evidence is limited in scope. Proving that rubella vaccination can cause chronic arthritis will require a better understanding of pathogenetic mechanisms and additional well-designed studies. We briefly describe the committee's evaluative methods and present the evidence underlying its conclusion. This content is only available as a PDF. © 1992 by The University of Chicago
TI - Chronic Arthritis after Rubella Vaccination
JF - Clinical Infectious Diseases
DO - 10.1093/clinids/15.2.307
DA - 1992-08-01
UR - https://www.deepdyve.com/lp/oxford-university-press/chronic-arthritis-after-rubella-vaccination-ZPDg6NNW5T
SP - 307
EP - 312
VL - 15
IS - 2
DP - DeepDyve
ER -