TY - JOUR
AU - LARSEN, WILLIAM, E.
AB - Abstract IN 1941, Albright while searching for serum phosphatase elevation in acromegalics (which incidentally he failed to find) noted significant elevation of the serum inorganic phosphorus in these patients. In going over the records of the same group of acromegalics, one of us became aware of certain significant findings and evolved therefrom a dual hypothesis. The findings were: First, that as above noted, almost all untreated acromegalics had abnormally high serum inorganic phosphorus values; the only exceptions were a few female acromegalics who still had normal ovarian function, and one acromegalic who had concomitant hyperparathyroidism. Second, that a prompt fall in serum phosphorus occurred in a few acromegalics who had received estrogen administered on the basis of the observations of Kirklin and Wilder (1). Third, examination of the literature revealed that growing children without exception have an elevation of the serum phosphorus, such elevation being roughly proportional to the prepubertal rate of growth, and that during the second (pubertal—“steroid induced”) growth spurt, the serum phosphorus falls to normal levels(2). Some of these observations were reported in abstract form in 1946(3). This content is only available as a PDF. Author notes * Read before the Thirtieth Annual Meeting of the Association for the Study of Internal Secretions, Chicago, Illinois, June 19, 1948. ** This work has been performed under a contract between the University of California and the Office of Naval Research. † Lt. (j.g.) M.C., U.S.N. Copyright © 1948 by The Endocrine Society
TI - STUDIES IN GROWTH: I. INTERRELATIONSHIP BETWEEN PITUITARY GROWTH FACTOR AND GROWTH-PROMOTING ANDROGENS IN ACROMEGALY AND GIGANTISM: II. QUANTITATIVE EVALUATION OF BONE AND SOFT TISSUE GROWTH IN ACROMEGALY AND GIGANTISM
JF - Journal of Clinical Endocrinology and Metabolism
DO - 10.1210/jcem-8-12-1013
DA - 1948-12-01
UR - https://www.deepdyve.com/lp/oxford-university-press/studies-in-growth-i-interrelationship-between-pituitary-growth-factor-ZNqFsWVi2G
SP - 1013
EP - 1036
VL - 8
IS - 12
DP - DeepDyve
ER -