TY - JOUR
AU - Thomas, A
AB - p COMPARISON OF THE EFFECTIVENESS OF SEVERAL DISINTEGRANTS IN CAPSULES OF 4-ETHOXYCARBONYLPHENOXY-2'-PYRIDYL METHANE (BRL 10614) J. Ryder, A. Thomas, Beecham Pharmaceuticals, Randalls Road, Leatherhead, Surrey The use of disintegrants to improve the bioavailability of drugs formulated into hard gelatin capsules has been reported in the literature (Newton & Razzo, 1974; Newton & Rowley, 1975). One may expect the use of disintegrants to be particularly important where a high dose drug is to be filled by a process involving compression. This communication reports a comparison of the effects of four disintegrants in capsules containing 500mg of BRL 10614, a cohesive, crystalline, chemically stable, basic drug. The capsules were filled by Zanasi LZ 64, which dosed a soft cylindrical plug of filling mix into each shell. The purpose of the study was to formulate capsules which could be filled with acceptable weight uniformity on available machinery, which would have a rapid in-vitro dissolution rate, and which would be chemically and physically stable for at least eighteen months. Initially small batches of capsules were made for measurement of dissolution rates in 0.06 N HC1 by a stirred flask method (see Table). The dissolution Increasing the rate was enhanced by 1.5 and 3% 
TI - A Comparison of the Effectiveness of Several Dis Integrants in Capsules of 4-Ethoxycarbonylphenoxy-2′-Pyridyl Methane (BRL 10614)
JO - Journal of Pharmacy and Pharmacology: An International Journal of Pharmaceutical Science
DO - 10.1111/j.2042-7158.1977.tb11531.x
DA - 1977-12-01
UR - https://www.deepdyve.com/lp/oxford-university-press/a-comparison-of-the-effectiveness-of-several-dis-integrants-in-ZLis7zq1kG
SP - 63P
EP - 63P
VL - 29
IS - Supplement_1
DP - DeepDyve
ER -