TY - JOUR
AU - Al-Bustan, Suzanne A.
AB - BACKGROUND:Non-Hodgkin’s lymphoma (NHL) is the most common hematological malignancy in the world. Many etiologic factors have been implicated in the risk of developing NHL, including genetic susceptibility and obesity. Single-nucleotide polymorphisms (SNPs) in Ghrelin (GHRL), an anti-inflammatory hormone, and tumor necrosis factor α (TNF-α), an inflammatory cytokine, have been independently associated with the risk for obesity and NHL.OBJECTIVE:To investigate the association between SNPs in GHRL and TNF-α and the risk for NHL and obesity in Kuwaitis.METHODS:We recruited 154 Kuwaiti NHL patients and 217 controls. Genotyping was performed for rs1629816 (GHRL promoter region), rs35684 (GHRL 3’ untranslated region), and rs1800629 (TNF-α promoter region). Logistic regression analysis was performed to assess the association of the investigated SNPs with NHL and the relationship between the selected SNPs with BMI in each group separately.RESULTS:We show that rs1629816 GG was associated with an increased risk for NHL in our sample (p= 0.0003, OR 1.82; CI: 1.31–2.54). None of the investigated SNPs were associated with obesity, nor was obesity found to be associated with the risk for NHL.CONCLUSIONS:Our study demonstrates an association between rs1629816, a SNP in the GHRL regulatory region, and NHL in Kuwaitis.
TI - Association analysis of genetic variants in the ghrelin and tumor necrosis factor α genes and the risk for non-Hodgkin’s lymphoma in Kuwaitis
JF - Cancer Biomarkers
DO - 10.3233/CBM-200373
DA - 2021-08-24
UR - https://www.deepdyve.com/lp/ios-press/association-analysis-of-genetic-variants-in-the-ghrelin-and-tumor-Z9C6Tz3YXk
SP - 11
EP - 18
VL - 32
IS - 1
DP - DeepDyve
ER -