TY - JOUR
AU - Michel, M., F.
AB - Abstract Cell-bound and extracellular autolytic activity was studied in a tolerant and a nontolerant Staphylococcus aureus strain after exposure to low (10 mg/l) and high (80 mg/l) concentrations of methicillin. Tolerance was defined as survival after 24 h of over 2% of the inoculum after exposure to high concentrations of methicillin (≥ 64 mg/l). The nontolerant strain showed an increased cell-bound autolytic activity after exposure to both low and high concentrations of methicillin. The tolerant strain on the other hand selectively showed a reduced cell-bound autolytic activity after exposure to 80 mg/l of methicillin. In both types of strains extracellular activity was less after exposure to a high concentration of methicillin than after exposure to a low concentration. This phenomenon was caused by the release of an inhibitor of the autolysins under the influence of the high concentration of methicillin. This content is only available as a PDF. © 1986, by The British Society for Antimicrobial Chemotherapy
TI - Cell-bound and extracellular autolytic activity of a tolerant and a nontolerant Staphylococcus aureus strain exposed to methicillin
JF - Journal of Antimicrobial Chemotherapy
DO - 10.1093/jac/18.4.459
DA - 1986-10-01
UR - https://www.deepdyve.com/lp/oxford-university-press/cell-bound-and-extracellular-autolytic-activity-of-a-tolerant-and-a-Z83OQzQxWy
SP - 459
EP - 466
VL - 18
IS - 4
DP - DeepDyve
ER -