TY - JOUR
AU - Sherief, Tahra
AB - Background Obese children are at increased risk for abnormal cardiac structure and function. Little is known about adre- nomedullin (AM), a cytokine produced in various organs and tissues, as a biomarker of cardiac hypertrophy in obese children. This study aimed to assess the plasma AM levels in a cohort of obese children and its relationship to left ventricular (LV) functions. Methods The study included 60 obese children and 60 non-obese children matched for age and gender as control group. Blood pressure, serum lipid profile, fasting glucose, insulin and plasma AM and the homeostatic model assessment of insulin resistance (HOMA-IR) were measured. Cardiac dimensions and LV functions were assessed using conventional echocardiography. Results Compared to control subjects, obese children had higher blood pressure (P = 0.01), insulin (P = 0.001), HOMA-IR (P = 0.001), and AM (P = 0.001). Moreover, obese children had higher LV mass index (LVMI) (P = 0.001), indicating LV hypertrophy; prolonged isovolumic relaxation times (P = 0.01), prolonged mitral deceleration time (DcT) (P = 0.01) and reduced ratio of mitral E-to-mitral A-wave peak velocity (P = 0.01), indicating LV diastolic dysfunction. Laboratory abnor- malities were only present in children with LV hypertrophy. In multivariate analysis in obese children with LV hypertrophy, AM levels were positively correlated with LVMI [odds ratio (OR) 1.14, 
TI - Plasma adrenomedullin level in children with obesity: relationship to left ventricular function
JF - World Journal of Pediatrics
DO - 10.1007/s12519-017-0106-6
DA - 2018-02-06
UR - https://www.deepdyve.com/lp/springer-journals/plasma-adrenomedullin-level-in-children-with-obesity-relationship-to-YVEU7dpbmB
SP - 84
EP - 91
VL - 14
IS - 1
DP - DeepDyve
ER -