TY - JOUR
AU1 - PAINTRAND,, Michel-Rene
AU2 - PIGNOT,, Isabelle
AB - Abstract An ultrastructural investigation on P388 murine leukemia in viva shows that navelbine, a new semi-synthetic anticancer drug belonging to the group of Vinca alkaloids, induces total depolymerization of microtubules, apparently without causing a concomitant aggregation of intermediate filaments. The accumulation of inclusion bodies, consisting of ribosome clusters and abnormally large tubules, suggests a stimulation of microtubular protein synthesis. In addition, the appearance of intracytoplasmic paired cisternae differentiated from the endoplasmic reticulum seems to be directly related to microtubule depolymerization. navelbine, microtubule paracrystal, mixed inclusion body, intermediate filament This content is only available as a PDF. © 1998 Medical Council on Alcoholism
TI - Navelbine: An Ultrastructural Study of Its Effects
JF - Journal of Electron Microscopy
DO - 10.1093/oxfordjournals.jmicro.a050401
DA - 1983-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/navelbine-an-ultrastructural-study-of-its-effects-YI5oPPjcwL
SP - 115
EP - 124
VL - 32
IS - 2
DP - DeepDyve
ER -