TY - JOUR
AU - Verjans, Georges M. G. M.
AB - Specific mutations within the hypervariable herpes simplex virus (HSV) gene thymidine kinase (TK) gene lead to acyclovir (ACV) resistance. To uncover the existence of latent ACV-resistant (ACVR) HSV-1, we determined the genetic and functional variability of the HSV-1 TK gene pool in paired trigeminal ganglia (TG) of 5 immunocompetent individuals. The latent virus pool consisted of a donor-specific HSV-1 quasispecies, including one major ACV-sensitive (ACVS) and multiple phylogenetic-related minor ACVS and ACVR TK variants. Contrary to minor variants, major TK variants were shared between paired TG. The data demonstrate the coexistence of phylogenetic-related ACVS and ACVR latent HSV-1 in human TG.
TI - Latent Acyclovir-Resistant Herpes Simplex Virus Type 1 in Trigeminal Ganglia of Immunocompetent Individuals
JO - Journal of Infectious Diseases
DO - 10.1093/infdis/jis237
DA - 2012-05-15
UR - https://www.deepdyve.com/lp/oxford-university-press/latent-acyclovir-resistant-herpes-simplex-virus-type-1-in-trigeminal-YGCENL4xQR
SP - 1539
EP - 1543
VL - 205
IS - 10
DP - DeepDyve
ER -