TY - JOUR
AU - Lefrère, Jean‐Jacques
AB -  A novel human parvovirus, called human parvovirus 4 (PARV4), distinct from other currently known parvoviruses infecting both humans and animals, has been identified in the plasma of a patient with symptoms of acute virus infection. Its transmission via blood and plasma‐derived products is probable, although not formally demonstrated by the description of a case of donor to recipient transmission. No chronic or acute clinical manifestation has been associated with the virus. Some recent articles have reported a 3% to 11% prevalence of PARV4 in individuals at risk of blood‐borne agents and a 4% to 21% prevalence in plasma pools used in the manufacture of plasma‐derived medicinal products. However, data on the prevalence of PARV4 in individual blood donations are yet limited, and no study has been published on this prevalence in recipients of cellular blood products. We have looked for PARV4 DNA in two groups: 1) 78 individuals belonging to a cohort of nonimmunodeficient patients multiply transfused with red blood cells (RBCs) for anemia related to a congenital hemoglobinopathy (thalassemia major or sickle cell disease) and selected as having received more than 100 RBC units over their life. All lived in the Paris area and were prospectively followed 
TI - Human parvovirus 4 in recipients of cellular products and in blood donors: epidemiologic similarity with B19 parvovirus
JO - Transfusion
DO - 10.1111/j.1537-2995.2009.02286.x
DA - 2009-08-01
UR - https://www.deepdyve.com/lp/wiley/human-parvovirus-4-in-recipients-of-cellular-products-and-in-blood-Y4tHt4isUc
SP - 1771
VL - 49
IS - 8
DP - DeepDyve
ER -