TY - JOUR
AU - Hasan , , Aurangzeb
AB -  A group of four series (Α-D) of 22 new bioactive 1-N-acid substituted 3, 5-diphenyl-2-pyrazolines were synthesized by cyclization of variably substituted chalcones and simple or substituted phenyl hydrazine and / or semicarbazide, using acetic acid as a solvent. The chemical structure of the compounds was characterized by FTIR, 'HNMR, and EIMS spectroscopy and chemical analyses. The antifungal and antibacterial activities of these compounds were evaluated by agar tube dilution method and agar well diffusion method respectively. Introduction In continuation of our previous work [1 ' on the synthesis of pyrazolines which have displayed various biological properties such as pesticidal, fungicidal, insecticidal, anti-inflammatory, antiarthritic, antidepressant and antiviral activitiesI2\"41. Considerable interest has been focused on the pyrazolines structure, which is known to possess a broad spectrum of biological activities such as transquillising, muscle relaxant, psychoanaleptic, anticonvulsant and antihypertensive activities [5 9). Moreover, these heterocyclic compounds, in addition to biological activities have also shown some industrial applications like bleaching agent, dyes, optical brighteners and various fluorescentwhitening agents | 2 , 4 ' l0\"13). Earlier studies by E. Palaska, et al. [l41 also demonstrated the antidepressant activities of some 3, 5-diphenyl-2pyrazolines. The present study is therefore devoted to the synthesis of pyrazolines 
TI - SYNTHESIS OF SOME NEW BIOACTIVE 1-N-SUBTITUTED 3, 5-DIARYL-2- PYRAZOLINES
JF - Heterocyclic Communications
DO - 10.1515/HC.2007.13.2-3.131
DA - 2007-06-01
UR - https://www.deepdyve.com/lp/de-gruyter/synthesis-of-some-new-bioactive-1-n-subtituted-3-5-diaryl-2-Xv2o8j1UL9
SP - 131
VL - 13
IS - 
DP - DeepDyve
ER -