TY - JOUR
AU - Ariad, Shmuel
AB - Background: Preoperative radio-chemotherapy (RCT)may play an important role in decreasing local recurrenceand possibly improving survival for patients withadvanced rectal carcinoma. Patients and Methods: Between1995 and 1998 we treated 30 patients (pts) (medianage 61.5 years) with advanced low rectal cancer. Radiotherapywas administered using a 10-MV linear acceleratordelivering a total dose of 45 Gy to the pelvis over5 weeks. 5-FU (500 mg/m2/d i.v.) was given concomitantlyon days 1-3 and 29-31. Surgery was performed2-4 weeks after RCT and included abdomino-perineal resection(APR) in 15 pts, anterior resection in 11 pts,transanal resection in 1 pt, and explorative laparotomy in1 pt; 2 pts refused surgery. Results: There were no serioustoxicities associated with RCT. Mild to moderatetransient radiation dermatitis was noted in 3 pts, andgrade II diarrhea in 4 pts. Postoperative pathologic stagingwas as follows: no tumor found (CR): 4 pts, MAC B1(T2N0M0): 5 pts, MAC B2 (T3N0M0): 17 pts, B3 (vaginal involvement):1 pt, MAC C2 (T3N1M0): 2 pts, and MAC D:1 pt. Necrosis and/or fibrosis was noted as a prominenthistopathologic feature. Conclusion: Preoperative RCT inthis series of 30 pts with advanced rectal cancer was welltolerated and associated with a high response rate (13%CR, 17% PR, 57% NC). 5-year overall survival was 70%,and 8-year survival was 58%.
TI - Preoperative Radio-Chemotherapy Treatment in Locally Advanced Rectal Carcinoma. Results of 8-Year Follow-Up
JF - Oncology Research and Treatment
DO - 10.1159/000085062
DA - 2005-05-01
UR - https://www.deepdyve.com/lp/karger/preoperative-radio-chemotherapy-treatment-in-locally-advanced-rectal-Xp0XfrkQ1L
SP - 267
EP - 269
VL - 28
IS - 5
DP - DeepDyve
ER -