TY - JOUR
AU - Martino, Gianvito
AB - REVIEW URRENT Neural stem cell transplantation in central nervous PINION system disorders: from cell replacement to neuroprotection a,b a,b a Donatella De Feo , Arianna Merlini , Cecilia Laterza , and a,b Gianvito Martino Purpose of review Transplantation of neural stem/precursor cells (NPCs) has been proposed as a promising therapeutic strategy in almost all neurological disorders characterized by the failure of central nervous system (CNS) endogenous repair mechanisms in restoring the tissue damage and rescuing the lost function. Nevertheless, recent evidence consistently challenges the limited view that transplantation of these cells is solely aimed at protecting the CNS from inflammatory and neurodegenerative damage through cell replacement. Recent findings Recent preclinical data confirmed that transplanted NPCs may also exert a ‘bystander’ neuroprotective effect and identified a series of molecules – for example, immunomodulatory substances, neurotrophic growth factors, stem cell regulators as well as guidance molecules – whose in-situ secretion by NPCs is temporally and spatially orchestrated by environmental needs. A better understanding of the molecular and cellular mechanisms sustaining this ‘therapeutic plasticity’ is of pivotal importance for defining crucial aspects of the bench-to-beside translation of neural stem cell therapy, that is route and timing of administration as well as the 
TI - Neural stem cell transplantation in central nervous system disorders  from cell replacement to neuroprotection
JF - Current Opinion in Neurology
DO - 10.1097/WCO.0b013e328352ec45
DA - 2012-06-01
UR - https://www.deepdyve.com/lp/wolters-kluwer-health/neural-stem-cell-transplantation-in-central-nervous-system-disorders-XjChsmAljs
SP - 322–333-322&ndash
EP - ndash;333-322–333
VL - 25
IS - 3
DP - DeepDyve
ER -