TY - JOUR
AU - Brazzelli, V.
AB - Research letter Incidence of human cytomegalovirus infection was asymptomatic; HCMV-DNAaemia was associated with and T-cell response in patients with psoriasis transient presence of HCMV-specific IgM. HCMV-specific T- before and during antitumour necrosis factor-a cell frequency was similar to that of other patients. In the sec- therapy ond patient, HCMV-DNAaemia lasted longer (> 110 days); psoriasis-related clinical symptoms were exacerbated on first DOI: 10.1111/bjd.15650 HCMV detection, thus anti-TNF-a therapy was stopped. The appearance of HCMV DNAaemia was followed by a short rise + + DEAR EDITOR, Psoriasis is a chronic inflammatory skin disease in HCMV-specific CD4 and CD8 T cells, which subsequently affecting ~2–3% of the world population. Among the cytoki- decreased in number concomitantly with the decrease/disap- nes produced by T cells, tumour necrosis factor (TNF)-a has a pearance of HCMV DNAaemia. 2 + + crucial role in psoriasis. Thus, TNF-a-blocking therapy is effi- The numbers of CD4 and CD8 T cells in group A patients cient in the treatment of psoriasis. before therapy were not significantly different from those of TNF-a inhibitors can increase the risk for latent tuberculosis controls (Fig. S1; see Supporting Information). However, an + + reactivation, but little is known about their effects during 
TI - Incidence of human cytomegalovirus infection and T‐cell response in patients with psoriasis before and during antitumour necrosis factor‐α therapy
JO - British Journal of Dermatology
DO - 10.1111/bjd.15650
DA - 2017-12-01
UR - https://www.deepdyve.com/lp/oxford-university-press/incidence-of-human-cytomegalovirus-infection-and-t-cell-response-in-XeeNaBL8l7
SP - e323
EP - e324
VL - 177
IS - 6
DP - DeepDyve
ER -