TY - JOUR
AU1 - Schueler, Fred W.
AB - II. A METHOD FOR THE DIFFERENTIAL STAINING OF NORMAL AND DRUG RESISTANT TRY­ PANOSOMES AND ITS POSSIBLE RELATION TO THE MECHANICS OF DRUG RESISTANCE* FRED W. SCHUELER From the Department of Pharmacology, The University of Chicago Since the time of Ehrlich' trypano­ owe their toxicity to a great affinity for somes ha ve been made resistant to a -SH groups suggested that resistant great many different dyes, arsenicals, trypanosomes may have large stores and antimonials.v'! Several strains of of accumulated -SH groups with which trypanosomes differ greatly in the de­ to detoxify arsenicals. This idea implied gree to which they are resistant to that the accumulation of arsenicals by various drugs, and they may also ex­ resistant trypanosomes would be as hibit certain unusual cross-resistance great as, if not greater than, that of phenomena between drugs of widely normal parasites. This hypothesis has different chemical character. Thus, try­ been tested by various investigators panosomes made resistant to acriflavine with the result that some workers'P-I! also may be resistant to certain arseni­ did not find a significant difference in 5 s cals. - Trypanosomes made resistant the arsenic bound by resistant and normal trypanosomes, while others,7 ,8 to one amino- 
TI - The Mechanism of Drug Resistance in Trypanosomes
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/81.2.139
DA - 1947-09-01
UR - https://www.deepdyve.com/lp/oxford-university-press/the-mechanism-of-drug-resistance-in-trypanosomes-XRcIMo9V4e
SP - 139
EP - 146
VL - 81
IS - 2
DP - DeepDyve
ER -