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Left : two mammalian polysialyltransferases, ST8Sia-II and ST8Sia-IV, are shown as blue and gold transmembrane molecules facing the Golgi lumen. Each independently transfers polysialic acid primarily to NCAM on its fifth immunoglobulin-like (lg-like) domain (gray oval) at the terminus of two specific N -linked glycans (black triangles). Interactions between each transferase and NCAM's first fibronectin type III repeat (gray cylinder) are required to position the enzyme active site. Middle : all three NCAM isoforms, which differ in their membrane and intracellular domains, are acceptors for polysialylation. Right : ST8Sia-II (blue) also adds polysialic acid to the first lg-like domain of SynCAM 1, targeted via interactions with the SynCAM's second lg-like domain. See Schnaar, Ronald L., Rita Gerardy-Schahn, and Herbert Hildebrandt. Physiol Rev 94: 461–518 , 2014. Table of Contents Back Matter (PDF) Ed Board (PDF) Front Matter (PDF) Article Abstract I. PREFACE ON ACTIN ORGANIZATION AND CELL MECHANICS II. ACTIN DYNAMICS AND MECHANICS III. CELLULAR SCALE: DYNAMICS AND MECHANICS OF INTEGRATED ACTIN STRUCTURES IV. CONCLUSION AND PERSPECTIVE DISCLOSURES GRANTS ACKNOWLEDGMENTS REFERENCES Figures & Data Info PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Physiological Reviews. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Actin Dynamics, Architecture, and Mechanics in Cell Motility Message Subject (Your Name) has sent you a message from Physiological Reviews Message Body (Your Name) thought you would like to see the Physiological Reviews web site. Your Personal Message Print Citation Tools Actin Dynamics, Architecture, and Mechanics in Cell Motility Laurent Blanchoin , Rajaa Boujemaa-Paterski , Cécile Sykes , Julie Plastino Physiological Reviews Jan 2014, 94 (1) 235-263; DOI: 10.1152/physrev.00018.2013 Citation Manager Formats BibTeX EndNote (tagged) EndNote 8 (xml) RefWorks Tagged RIS Medlars Bookends Mendeley Request Permissions Share Actin Dynamics, Architecture, and Mechanics in Cell Motility Actin Dynamics, Architecture, and Mechanics in Cell Motility Laurent Blanchoin , Rajaa Boujemaa-Paterski , Cécile Sykes , Julie Plastino Physiological Reviews Jan 2014, 94 (1) 235-263; DOI: 10.1152/physrev.00018.2013 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section L-Type Ca V 1.2 Calcium Channels: From In Vitro Findings to In Vivo Function Targeting Aldehyde Dehydrogenase 2: New Therapeutic Opportunities Dendritic Spines: The Locus of Structural and Functional Plasticity Show more Articles Related Articles Web of Science Scopus PubMed Google Scholar Cited By... 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