TY - JOUR AU - Montanari, Luisa AB - The topical treatment with dimethyl sulfoxide (DMSO) and/or α-tocopherol (α-T) is widely used in order to prevent the local complications of extravasation of cytostatic drugs and protect patients against skin ulceration. Till now, DMSO and α-T have been mainly used in solution. The goal of this study was to formulate semisolid preparations for cutaneous application differing in the hydrophilic and lipophilic properties and containing DMSO and α-T in combination. With respect to solutions, the use of semisolid preparations containing DMSO and α-T could be advantageous in patients having extravasation as DMSO and α-T can remain in contact with the skin over an extended period of time. As a consequence, the action of the active principles can be limited specifically on the injured skin area, reducing the cutaneous irritative effects of DMSO. The following types of semisolid formulations containing 50% m/m DMSO and 2.5% m/m α-T were prepared: hydrophilic ointment, o/w emulsion, hydrophilic gel and lipophilic gel. The ex vivo skin permeation of DMSO and α-T was evaluated by using modified Franz’s diffusion cells and human stratum corneum and epidermis (SCE) as a membrane. The permeated and retained amounts of DMSO and α-T were determined. The oleogel preparation, the hydrophilic gel and the o/w emulsion were uniform in colour and aspect, without any evidences of phase separation over the period of the study. Hydrophilic ointments were discarded as they showed phase separation after 12 h. All formulations had a different behaviour in terms of skin permeability. In particular, hydrogel and o/w emulsion showed the best control on the drug release considering the interactions of the vehicle components with the SCE and the drugs partition between the vehicle and the SCE. The DMSO permeated amount after 24 h was 4.1 mg/cm2 for hydrogel and 2.5 mg/cm2 for emulsion while the permeated amount of pure DMSO after 24 h was 47.5 mg/cm2. Therefore, aiming to reduce side effects after the topical application of the antidotes DMSO and α-T, these results suggested that hydrogel and o/w emulsion could be considered the most promising formulations for further clinical evaluations in managing of extravasation of anthracyclines. TI - Semisolid formulations containing dimethyl sulfoxide and α-tocopherol for the treatment of extravasation of antiblastic agents JF - Archives of Dermatological Research DO - 10.1007/s00403-007-0746-9 DA - 2007-03-17 UR - https://www.deepdyve.com/lp/springer-journals/semisolid-formulations-containing-dimethyl-sulfoxide-and-tocopherol-XAHOtct1Fh SP - 201 EP - 207 VL - 299 IS - 4 DP - DeepDyve ER -