TY - JOUR
AU1 - Patterson, Roy
AU2 - Harris, Kathleen E.
AU3 - Bernstein, Peter R.
AU4 - Krell, Robert D.
AU5 - Handley, Dean A.
AU6 - Saunders, Robert N.
AB - Rhesus monkeys with IgE-mediated asthmatic-type responses to Ascaris suum antigen were pre-treated with a combination of 2 receptor antagonists to leukotriene D<sub>4</sub> (LTD<sub>4</sub>) and platelet-activating factor (PAF). This combination of anti-LTD<sub>4</sub> and anti-PAF was shown to inhibit airway responses to either LTD<sub>4</sub> or PAF in separate experiments in these Ascaris airway-reactive animals. When the same combination of LTD<sub>4 </sub>and PAF receptor antagonists was used to pretreat the same animal prior to aerosol challenge with Ascaris antigen we could not demonstrate inhibition of the antigen-induced airway response. Thus, combined receptor blockade for LTD<sub>4</sub> and PAF did not alter IgE-mediated acute airway responses to antigen in this species. We review the current status of rhesus asthma and LTD<sub>4</sub> and PAF receptor antagonist activity in this model.
TI - Effects of Combined Receptor Antagonists of Leukotriene D4(LTD4) and Platelet-Activating Factor (PAF) on Rhesus Airway Responses to LTD4, PAF and Antigen
JF - International Archives of Allergy and Immunology
DO - 10.1159/000234733
DA - 1989-01-01
UR - https://www.deepdyve.com/lp/karger/effects-of-combined-receptor-antagonists-of-leukotriene-d4-ltd4-and-X7xQE60rjs
SP - 462
EP - 470
VL - 88
IS - 4
DP - DeepDyve
ER -