TY - JOUR
AU1 - Schauf, V.
AU2 - Nell, P.
AU3 - Ghaey, K.
AU4 - Tolpin, M.
AU5 - Rathi, M.
AU6 - Kontelas, B.
AU7 - Adkinson, N. F.
AB - THE JOURNAL OF INFECTIOUS DISEASES • VOL. 152, NO.5. NOVEMBER 1985 © 1985 by The University of Chicago. All rights reserved. 0022-1899/85/5205-0030$01.00 Hypersensitivity to f3-Lactam Antibiotics in Children Given Penicillin G or Placebo at Birth Penicillin G and semisynthetic penicillins are used fre­ to describe any possible allergic reactions that occurred quently in the neonatal period for therapy and for pro­ in association with f3-lactam administration, including rash, phylaxis of infection due to susceptible bacteria. These swelling, respiratory distress, or any combination of these agents are very well tolerated in newborn infants; how­ symptoms. Parents were also asked to describe any addi­ ever, the potential for f3-lactams to sensitize neonates is tional allergies they thought their child might have. A fam­ unknown. We investigated this question in a group of 420 ily history of penicillin allergy was sought. two-year-old children who had participated in a ran­ Antibodies to penicillin. Sera were stored at - 70 C domized, placebo-controlled trial of penicillin prophylaxis and assayed for IgG and IgE antibodies specific to the ma­ jor benzylpenicilloyl (BPO) antigen, as previously de­ of neonatal group B streptococcal disease [1]. scribed [2, 3]. Specifically, IgG antibody to BPO (BPO­ IgG) was measured 
TI - Hypersensitivity to β-Lactam Antibiotics in Children Given Penicillin G or Placebo at Birth
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/152.5.1074
DA - 1985-11-01
UR - https://www.deepdyve.com/lp/oxford-university-press/hypersensitivity-to-lactam-antibiotics-in-children-given-penicillin-g-X5psOoot3E
SP - 1074
EP - 1075
VL - 152
IS - 5
DP - DeepDyve
ER -