TY - JOUR
AU - Hopley, Chris
AB - The design and development of a novel extractive electrospray ionisation (EESI) device for on‐line reaction monitoring is described. The EESI apparatus uses a secondary, grounded nebuliser to produce an analyte aerosol and a Venturi pump is then used to transfer a sample of the aerosol to an electrospray source where it is ionised. The EESI apparatus was then tested with a variety of small, organic molecules to assess sensitivity, linearity and dynamic range. The performance of the technique will depend on the mass spectrometer used for the experiments; in the configurations used here it has a useable dynamic range of around 3.5 orders of magnitude with a linear range of around 2.5 orders of magnitude and is capable of analysing species present down to low µg/mL with signal‐to‐noise ratio greater than 2.5. The use of EESI for reaction monitoring was validated using a series of mock reaction mixtures and then used to monitor the base hydrolysis of ethyl salicylate to salicylic acid. Copyright © 2011 John Wiley & Sons, Ltd.
TI - On‐line reaction monitoring by extractive electrospray ionisation
JO - Rapid Communications in Mass Spectrometry
DO - 10.1002/rcm.5016
DA - 2011-01-30
UR - https://www.deepdyve.com/lp/wiley/on-line-reaction-monitoring-by-extractive-electrospray-ionisation-X2G7RxIS4Q
SP - 1445
EP - 1451
VL - 25
IS - 10
DP - DeepDyve
ER -