TY - JOUR
AU - Lind, Lars
AB - Context:Vitamin D plays a role in a wide range of extraskeletal processes, including vascular function. Endothelial dysfunction is a predictor of cardiovascular disease, especially in older subjects. However, the relationship between vitamin D levels and indexes of endothelial vasodilation has never been fully addressed in older individuals.Objective:The objective of this study was to examine the association between vitamin D and endothelial function in a large community-based sample of older subjects.Methods:This cross-sectional study involved 852 community-dwelling men and women aged 70 years from the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS), with complete data on vascular function and 25-hydroxyvitamin D. We evaluated endothelium-dependent vasodilation by an invasive forearm technique with acetylcholine, endothelium-independent vasodilation by sodium nitroprussiate, flow-mediated vasodilation, and the pulse wave analysis (reflectance index). Vitamin D levels were measured by chemiluminescence. We used multivariate regression models adjusted for body mass index (model 1) and for multiple confounders (high-sensitivity C-reactive protein, insulin, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, smoking, sex hormones, season of blood collection, hypertension, diabetes, cardiovascular medications and diseases, statin usage, plasma calcium and calcium intake, PTH, physical exercise, liver and kidney function tests, albumin; model 2).Results:In women, but not in men, vitamin D levels were positively associated with endothelium-independent vasodilation in both model 1 (β ± SE = 1.41 ± 0.54; P = .001), and model 2 (β ± SE = 2.01 ± 0.68; P = .003).We found no significant relationship between vitamin D levels and endothelium-dependent vasodilation, flow-mediated vasodilation, and reflectance index in both sexes.Conclusions:In older women, but not in men, vitamin D is positively and independently associated with EIDV.
TI - Vitamin D and Endothelial Vasodilation in Older Individuals: Data From the PIVUS Study
JF - Journal of Clinical Endocrinology and Metabolism
DO - 10.1210/jc.2014-1536
DA - 2014-09-01
UR - https://www.deepdyve.com/lp/oxford-university-press/vitamin-d-and-endothelial-vasodilation-in-older-individuals-data-from-Wz1yB0H0Jc
SP - 3382
EP - 3389
VL - 99
IS - 9
DP - DeepDyve
ER -