TY - JOUR
AU - Tang,, Lin
AB - The main clinical manifestations of DM included proximal skeletal muscle weakness and cutaneous lesions (heliotrope periorbital oedema, Gottron papules and sign, mechanician hands, shawl and V-sign, and holster sign) [1, 2]. Subcutaneous calcification is a relatively rare manifestation of cutaneous lesions in adults. A 28-year-old man who had a 2-year history of DM presented with a symmetrical proximal muscle weakness and cutaneous eruption. Physical examination revealed violaceous plaques on the metacarpophalangeal joints. Proximal muscle strength was 5– according to the Lovett scale. Laboratory findings revealed elevated ESR and CRP. Anti-MDA5 antibodies were positive. Electromyography suggested myogenic lesions. MRI presented a high signal of proximal skeletal muscle on the T2-weighted image (T2WI). Muscle biopsy confirmed the diagnosis of DM. This patient was treated with prednisolone and tacrolimus regularly. He visited our department complaining of the hardened skin of his chest and armpit that had been detected in the past 5 months. High-resolution CT indicated interstitial lung disease and extensive punctate high-density shadows in the subcutaneous fat interval of his chest and armpit (Fig. 1). Extensive subcutaneous calcification is a rare manifestation of DM and mostly occurs in juveniles. Rheumatologists must be aware of this kind of clinical manifestation in adult patients with anti-MDA5 antibodies. Fig. 1 View largeDownload slide Chest CT showing extensive subcutaneous calcification in subcutaneous fat interval of chest and armpit (arrows) Fig. 1 View largeDownload slide Chest CT showing extensive subcutaneous calcification in subcutaneous fat interval of chest and armpit (arrows) Funding: This manuscript was supported by grant 81771738 from the National Natural Science Foundation of China. Disclosure statement: The authors have declared no conflicts of interest. References 1 Gruntová Z , Drlík L , Slezáková L , Pat’avová V. Dermatomyositis . Cas Lek Cesk 2016 ; 155 : 29 – 33 [in Czech] . Google Scholar PubMed 2 Kurtzman DJB , Vleugels RA. Anti-melanoma differentiation-associated gene 5 (MDA5) dermatomyositis: a concise review with an emphasis on distinctive clinical features . J Am Acad Dermatol 2018 ; 78 : 776 – 85 . Google Scholar Crossref Search ADS PubMed © The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
TI - Extensive subcutaneous calcification: a rare manifestation of dermatomyositis
JF - Rheumatology
DO - 10.1093/rheumatology/key395
DA - 2019-06-01
UR - https://www.deepdyve.com/lp/oxford-university-press/extensive-subcutaneous-calcification-a-rare-manifestation-of-WGQ4Y5RvoI
SP - 974
VL - 58
IS - 6
DP - DeepDyve
ER -