TY - JOUR
AU - SEINO, YOSHIKI
AB - Acta Paediatnca Japonica (1 997) 39,478 Foreword YOSHIKI SEINO Department of Pediatrics, Okayama University Medical School, Okaytima, Japun Generally, metabolic bone diseases have been considered various types, In recent years, techniques in genetic intractable. Most of these diseases are diagnosed based diagnosis have rapidly advanced. Gene mutations have on physical findings relatively soon after birth. The been detected in patients with these diseases, facilitating emotional stress of the patient’s parents at diagnosis is genetic diagnosis. Therefore, the accuracy of diagnosis has improved by using genetic diagnosis in combination with marked. Metabolic bone diseases cause developmental disorders, standard X-ray findings. In this special issue, we report the recent advances in genetic diagnostic methods. inducing bone deformity and a predisposition to fracture. For example, in patients with achondroplasia, the final Furthermore, advances in treatment include admini- height for males and for females is approximately 130 cm stration of active vitamin D for hypocalcemia and rickets, administration of human growth hormones for short stature and 120 cm, respectively. Clinically, there are two major issues related to in patients with achondroplasia, and administration of calcitonin or bisphosphonate for fracture in patients with metabolic bone diseases. First, metabolic bone diseases are difficult to diagnose 
TI - Metabolic bone diseases
JF - Pediatrics International
DO - 10.1111/j.1442-200X.1997.tb03623.x
DA - 1997-01-01
UR - https://www.deepdyve.com/lp/wiley/metabolic-bone-diseases-W4SL1i6P7k
SP - 478
EP - 478
VL - 39
IS - 4
DP - DeepDyve
ER -