TY - JOUR
AU - Kessler, Robert M.
AB - Abstract • Local cerebral uptake of deoxyglucose labeled with fluorine 18 was measured by positron emission tomography in 16 patients with schizophrenia and 11 patients with affective disorder. Patients received no medication a minimum of 14 days and an average of 39.8 days. The subjects were administered the deoxyglucose 18F just before receiving a 34-minute 1/s series of unpleasant electrical stimuli to the right forearm while resting with eyes closed in a darkened, acoustically attenuated psychophysiologic testing chamber. Following monitored stimulation in the controlled environment, subjects were scanned and images converted to values of glucose use in micromoles per 100 g per minute according to Sokoloff's model. Data were analyzed with a four-way analysis of variance (ANOVA) with independent groups (normals, schizophrenics, and affectives) and repeated measures for slice level (supraventricular, midventricular, and infraventricular), hemisphere (right, left), and anteroposterior position (four sectors). Both normal subjects and patients showed a significant anteroposterior gradient in glucose use with highest values in the frontmost sector. Patients both with schizophrenia and with affective illness showed less of an anteroposterior gradient especially at superior levels, which was statistically confirmed by ANOVA. Absolute glucose levels in patients, which were actually higher in posterior regions rather than lower in frontal regions, were the largest contributors to the effect. Neither group differences in whole brain glucose use nor left-right asymmetries reached statistical significance. 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TI - Anteroposterior Gradients in Cerebral Glucose Use in Schizophrenia and Affective Disorders
JF - Archives of General Psychiatry
DO - 10.1001/archpsyc.1984.01790230045007
DA - 1984-12-01
UR - https://www.deepdyve.com/lp/american-medical-association/anteroposterior-gradients-in-cerebral-glucose-use-in-schizophrenia-and-VJQbzmaNCS
SP - 1159
EP - 1166
VL - 41
IS - 12
DP - DeepDyve
ER -