TY - JOUR
AU - Gurewich, Victor
AB - Abstract Measurement of fibrin degradation products (FDP) was evaluated in 152 consecutive patients referred because diagnosis of deep vein thrombosis (DVT) was suspected. All patients underwent impedance plethysmography (IPG), and venograms were obtained in 59. Sensitivity and specificity of FDP measurement, using venography as the standard, was 88% and 66%, respectively. Sensitivity and specificity of IPG was 77% and 79%, respectively. Specificity of the two tests combined, when both yielded abnormal results, was 93%. Patients were classified as (1) normal, (2) abnormal, or (3) equivocal on the basis of IPG. A significant difference in mean FDP concentration was found between groups 1 and 2 and groups 2 and 3. An overall correlation was found between degree of abnormality on IPG and FDP concentration. A quantitative determination of FDP is a practical and reliable screening test for DVT and, when used in conjunction with IPG, improves both sensitivity and specificity of the latter. (Arch Intern Med 140:903-906, 1980) References 1. Johnson WB: Evaluation of techniques for the diagnosis of venous thrombosis . J Surg Res 16:473-481, 1974.Crossref 2. Kakkar VV, Howe CT, Flanc C, et al: Natural history of postoperative deep-vein thrombosis . Lancet 2:230-232, 1969.Crossref 3. Albrechtson U, Olsson C: Thrombotic side-effects of lower limb phlebography . Lancet 1:723-724, 1976.Crossref 4. Wheeler HB, Pearson D, O'Connell D, et al: Impedance phlebography . Arch Surg 104:164-169, 1972.Crossref 5. Wheeler HB, O'Donnell JA, Anderson FA, et al: Occlusive impedance phlebography: A diagnostic procedure for venous thrombosis and pulmonary embolism . Prog Cardiovasc Dis 27:199-205, 1974.Crossref 6. Wheeler HB, Anderson FA, Matesanz JM, et al: Impedance plethysmography: The diagnosis of venous thrombosis by occlusive impedance plethysmography , in Bernstein EF (ed): Noninvasive Techniques in Vascular Disease . St Louis, CV Mosby Co, 1978, pp 359-373. 7. Hull R, Van Aken WG, Hirsh H, et al: Impedance plethysmography using the occlusive cuff technique in the diagnosis of venous thrombosis . Circulation 53:696-700, 1976.Crossref 8. Hull R, Hirsh J, Sackett DL, et al: Combined use of leg scanning and impedance plethysmography in suspected venous thrombosis: An alternative to venography . N Engl J Med 296:1497-1500, 1977.Crossref 9. Ruckley CV, Das PC, Leitch AG: Serum fibrin/fibrinogen degradation products associated with postoperative pulmonary embolus and venous thrombosis . Br Med J 4:395-398, 1970.Crossref 10. Gurewich V, Hutchinson E: Detection of intravascular coagulation by a serial dilution protamine sulfate test . Ann Intern Med 75:895-902, 1971.Crossref 11. Sonnabend D, Cooper D, Fiddes P, et al: Fibrin degradation products in thrombo-embolic disease . Pathology 4:47-51, 1972.Crossref 12. Tibbutt DA, Chesterman CN, Allington MJ, et al: Measurement of fibrinogen-fibrin-related antigen in serum as aid to diagnosis of deep vein thrombosis in outpatients . Br Med J 1:367-369, 1975.Crossref 13. Gurewich V, Hume M, Patrick M: The laboratory diagnosis of venous thromboembolic disease by measurement of fibrinogen/fibrin degradation products and fibrin monomer . Chest 64:585-590, 1973.Crossref 14. Hull R, Taylor DW, Hirsh J: Impedance plethysmography: The relationship between venous filling and sensitivity and specificity for proximal vein thrombosis . Circulation 58:898-902, 1978.Crossref 15. Rabinov K, Paulin S: Roentgen diagnosis of venous thrombosis in the leg . Arch Surg 104:134-144, 1972.Crossref 16. Hawiger J, Niewiarowski S, Gurewich V, et al: Measurement of fibrinogen and fibrin degradation products in serum by staphylococcal clumping test . J Lab Clin Med 75:93-108, 1970. 17. Thomas DP, Niewiarowski S, Myers AR, et al: A comparative study of four methods for detecting fibrinogen degradation products in patients with various diseases . N Engl J Med 283:663-668, 1970.Crossref 18. Marder VJ, Matchett MO, Sherry W: Detection of serum fibrinogen and fibrin degradation products . Am J Med 51:71-82, 1971.Crossref 19. Gurewich V, Hyde E, Lipinski B: The resistance of fibrinogen and soluble fibrin monomer in blood to degradation by a potent plasminogen activator derived from cadaver limbs . Blood 46:555-565, 1975. 20. Rickman FD, Handin R, Howe JP, et al: Fibrin split products in acute pulmonary embolism . Ann Intern Med 79:664-668, 1973.Crossref 21. Bynum LJ, Parkey RW, Wilson JE: Tests of fibrin metabolism in recurrent venous thromboembolism . Arch Intern Med 137:1385-1392, 1977.Crossref 22. Lipinski B, Hawiger J, Jelijaszewicz J: Staphylococcal clumping with soluble fibrin monomer complexes . J Exp Med 126:979-988, 1967.Crossref
TI - Fibrin Degradation Products and Impedance Plethysmography
JF - Archives of Internal Medicine
DO - 10.1001/archinte.1980.00040020903005
DA - 1980-07-01
UR - https://www.deepdyve.com/lp/american-medical-association/fibrin-degradation-products-and-impedance-plethysmography-VCXH2PD5h7
SP - 903
EP - 906
VL - 140
IS - 7
DP - DeepDyve
ER -