TY - JOUR
AU - Guasti, Luigina
AB - Experimental evidence has suggested a possible relationship between LDL-cholesterol metabolism and the angiotensin converting enzyme system. Hypertension and diabetes-associated dyslipidemia contribute to enhance the cardiovascular risk in the diabetic population. The aim of this study was to investigate whether the complete blockade of the renin-angiotensin system (combination therapy with ACEi plus ARBs) in diabetic patients could modify the LDL plasma levels.Sixty-two patients (pts) with type 2 diabetes on treatment with Enalapril 10 mg/day and Sulphonylurea or Metformin were submitted to clinical evaluation (body-mass index -BMI-, blood pressure -BP-), 24-h ambulatory BP monitoring and to blood sampling for metabolic profile including HbA1c, LDLc and ApoB. Afterwards, in 50/62 pts, Valsartan 80 mg/day was added and the clinical parameters, BP and metabolic profile were re-evaluated after 3 months.In the 50 pts, at the first evaluation, the clinical BP was: 148±29/82±15 mmHg, pulse pressure (PP): 65±17 mmHg. The ambulatory BP was: 142±26/76±14 mmHg. The HbA1c was: 7.2±2 %. The lipid profile was: Total cholesterol 216±54 mg/dl, LDLc 132±40 mg/dl, HDL 49±16, tryglicerides 175±111 mg/dl, ApoA 136±32, ApoB 112±34.At the second evaluation, after 3 months of combination therapy, the BP was significantly reduced, as expected (133±29/74±16; PP: 59±18 mmHg; 24-hBP: 137±24/74±12 mmHg) (p<.01). The LDLc and the ApoB showed a significant reduction (paired t test: p<.002 and p<.005, respectively), in presence of unchanged BMI and HbA1c.The control group of 12 pts who did not agree to assume the combination therapy, no significant change was observed in BP or metabolic parameters.In conclusion, in hypertensive pts with type 2 diabetes, after three months of anti-hypertensive treatment achieving the complete block of the angiotensin system, a LDLc reduction was observed in the absence of changes in BMI or glycemic parameters. These results may suggest a possible influence of the angiotensin system on lipid metabolism in humans.
TI - P-503: Changes in LDL-cholesterol during complete blockade of the angiotensin system in patients with diabetes and hypertension
JO - American Journal of Hypertension
DO - 10.1016/S0895-7061(02)02854-6
DA - 2002-04-01
UR - https://www.deepdyve.com/lp/oxford-university-press/p-503-changes-in-ldl-cholesterol-during-complete-blockade-of-the-V2JJWQtA6v
SP - 214A
EP - 214A
VL - 15
IS - S3
DP - DeepDyve
ER -