TY - JOUR
AB - THE JOURNAL OF INFECTIOUS DISEASES. VOL. 137, NO.5. MAY 1978 DR. N. PIERCE. The discussions at this meeting DR. S. GORBACH. Let us return to the issue have mostly been concerned with noninvasive raised by Dr. King, the possibility that a micro­ bacteria that could potentially reside for a brief organism could elaborate a product and thereby period of time in the gut, or with the products cause an autoimmune disease in the host. Are of these organisms that could react with the host. there appropriate laboratory tests-for example, These products are usually delivered to an intact the cytotoxicity assays-to answer this question? mucosal surface in an immunologically normal in­ DR. SHORTER. Yes, it might be possible in a dividual. The model proposed by Dr. King rat model because rat colon cross-reacts with hu­ doesn't fit this situation for two reasons. First, a man colon-especially with the neonatal rat streptococcal pharyngeal infection.is not a gut model. Cross-reactivity would be the criterion, infection. There are anatomical and immunologi­ rather than the pathogenic effect of the E. coli cal differences between these organisms. The per se. pharynx lacks a submucosal layer of IgA cells and DR. PIERCE. These patients also have 
TI - Discussion
JF - The Journal of Infectious Diseases
DO - 10.1093/infdis/137.5.667
DA - 1978-05-01
UR - https://www.deepdyve.com/lp/oxford-university-press/discussion-UpfF61ofcP
SP - 667
EP - 667
VL - 137
IS - 5
DP - DeepDyve
ER -