TY - JOUR
AU1 - Zagon, Ian, S.
AU2 - McLaughlin, Patricia, J.
AU3 - Goodman, Steven, R.
AU4 - Rhodes, Randy, E.
AB - Abstract Receptor binding studies demonstrated specific high-affinity, saturable binding of a number of opioid ligands to a wide variety of neural and nonneural human and animal tumors. Radioimmunoassays revealed the presence of β-endorphin and methionine-enkephalin in these tumors. Both methionine- and leucine-enkephalin were detected in tumor tissue by immunocyto-chemistry, with immunoreactivity related to the cortical cytoplasm of tumor cells, but not to cell nuclei. Endogenous opioids and receptors were found in benign and malignant tumors representative of ectodermal, mesodermal, and endodermal origin. Receptors and endogenous opioid peptides were present in tumors from many different species, including those transplanted into nude mice. These results suggest that opioid receptors and endogenous opioids are fundamental features of human and animal cancers. 2 Supported by Public Health Service grants NS-20623 and NS-20500 from the National Institute of Neurological and Communicative Disorders and Stroke and by a grant from The Pennsylvania Research Corporation. 3 A preliminary report of these findings was presented at the 16th Annual Meeting of the Society of Neuroscience (Soc Neurosci 1986; 12:1170). This content is only available as a PDF. Author notes 4 Department of Anatomy, The Milton S. Hershey Medical Center (MSHMC), The Pennsylvania State University, Hershey, PA 17033. 5 Department of Physiology, MSHMC. 6 We are grateful to Ms. Sue Ditty and Ms. Laura Nagy for technical assistance; to Dr. A. Abt, Dr. J. Towfighi, Dr. T. McGarrity, and Dr. D. Stern for their assistance in obtaining human specimens; and to Dr. J. Lundeen for his thoughtful comments on the computer-assisted receptor binding analysis.
TI - Opioid Receptors and Endogenous Opioids in Diverse Human and Animal Cancers
JF - JNCI: Journal of the National Cancer Institute
DO - 10.1093/jnci/79.5.1059
DA - 1987-11-01
UR - https://www.deepdyve.com/lp/oxford-university-press/opioid-receptors-and-endogenous-opioids-in-diverse-human-and-animal-UVSbcXV8ZC
SP - 1059
EP - 1065
VL - 79
IS - 5
DP - DeepDyve
ER -