TY - JOUR
AU - Llacer, Angel
AB - AimsThe aim of the present study was to evaluate the involvement of the right ventricle (RV) in reperfused anterior ST-elevation myocardial infarction (STEMI).Methods and resultsLeft anterior descending (LAD)-perfused area (using thioflavin-S staining after selective infusion in proximal LAD artery, ), infarct size (using triphenyltetrazolium chloride staining, ), and salvaged myocardium ( of LAD-perfused area) in the right and left ventricle (LV) were quantified in a 90-min LAD occlusion 3-day reperfusion model in swine (n  8). Additionally, we studied, using cardiovascular magnetic resonance, 20 patients with a first STEMI due to proximal LAD occlusion treated with primary angioplasty. Area at risk (T2-weighted sequence, ), infarct size (late enhancement imaging, ), and salvaged myocardium ( of area at risk) in the right and LV were quantified. In swine, a large LAD-perfused area was detected both in the right and LV (30  5 vs. 62  15, P< 0.001) but more salvaged myocardium (94  6 vs. 73  11, P< 0.001) resulted in a smaller right ventricular infarct size (2  1 vs. 16  5, P< 0.001). Similarly, in patients a large area at risk was detected both in the right and LV (34  13 vs. 43  12, P  0.02). More salvaged myocardium (94  10 vs. 33  26, P < 0.001) resulted in a smaller infarct size (2  3 vs. 30  16, P< 0.001) in the RV.ConclusionIn reperfused extensive anterior STEMI, a large area of the RV is at risk but the resultant infarct size is small.
TI - Right ventricular involvement in anterior myocardial infarction: a translational approach
JF - Cardiovascular Research
DO - 10.1093/cvr/cvq091
DA - 2010-09-01
UR - https://www.deepdyve.com/lp/oxford-university-press/right-ventricular-involvement-in-anterior-myocardial-infarction-a-UHBehZ0Z3M
SP - 601
EP - 608
VL - 87
IS - 4
DP - DeepDyve
ER -