TY - JOUR
AU - Nicodemi, Mario
AB -  The exploration of the spatial organization of chromosomes in the cell nucleus has been greatly enhanced by genome-scale technologies such as Hi-C methods. Polymer models are helping to understand the new emerging complex scenarios and here we review some recent developments. In the cell nucleus of eukaryotes, chromosomes have a complex spatial organization serving vital functional purposes, with structural disruptions being linked to disease (Fraser and Bickmore, 2007 ; Lanctot et al., 2007 ; Misteli, 2007 ; Pombo and Branco, 2007 ). The development of technologies such as Hi-C (Lieberman-Aiden et al., 2009 ) has opened the way to mapping chromatin interactions at a genomic scale. It is emerging that chromosomes tend to form 1Mb sized domains with increased levels of intra-interactions (known, e.g., as Topological Domains, TDs) (Dixon et al., 2012 ; Nora et al., 2012 ), but contacts extend across entire chromosomes (Branco and Pombo, 2006 ; Shopland et al., 2006 ; Fraser and Bickmore, 2007 ; Kalhor et al., 2011 ; Sexton et al., 2012 ), as highlighted by the average contact probability of two sites, P c ( s ), which is non-zero also for large genomic separations, s . In particular, in the 
TI - Polymer models of chromatin organization
JF - Frontiers in Genetics
DO - 10.3389/fgene.2013.00113
DA - 2013-06-20
UR - https://www.deepdyve.com/lp/pubmed-central/polymer-models-of-chromatin-organization-U8PujvA8MS
VL - 4
IS - 
DP - DeepDyve
ER -