TY - JOUR
AU - Zhu, Dunming
AB - The cover picture shows two one‐pot processes for the bioenzymatic synthesis of ethyl (R)‐3‐hydroxyglutarate (EHG), a key intermediate for the synthesis of rosuvastatin, from ethyl (S)‐4‐chloro‐3‐hydroxybutyrate (ECHB). In their Full Paper Q. Wu, D. Zhu and co‐workers show how in a one‐pot two‐step process the intermediate ethyl (R)‐4‐cyano‐3‐hydroxybutyate (HN) can be synthesized by using Escherichia coli cells expressing a halohydrin dehalogenase gene, followed by hydrolysis to EHG with Escherichia coli cells expressing a nitrilase gene. The recombinant Escherichia coli cells co‐expressing halohydrin dehalogenase and nitrilase genes can be used in a one‐pot one‐step process to produce EHG directly. The article highlighted by this cover can be found on p. 1438 ff. of Issue 9, 2015.
TI - Cover Picture: Efficient Biosynthesis of Ethyl (R)‐3‐Hydroxyglutarate through a One‐Pot Bienzymatic Cascade of Halohydrin Dehalogenase and Nitrilase (ChemCatChem 9/2015)
JO - ChemCatChem
DO - 10.1002/cctc.201590046
DA - 2015-04-04
UR - https://www.deepdyve.com/lp/wiley/cover-picture-efficient-biosynthesis-of-ethyl-r-3-hydroxyglutarate-TkxmPi58aU
SP - 1387
EP - 1387
VL - 7
IS - 9
DP - DeepDyve
ER -