TY - JOUR
AU - STORSTEIN,, O.
AB - Abstract The acute hemodynamic effect of 0.5 mg strophanthin and the subsequent effect of 1.O mg pindolol was studied in seven patients with symptomatic hypertrophic cardiomyopathy. Three women and four men, average age 39.1 years (range 15–61), underwent right and left heart catheterization with simultaneous pressure recordings in the left ventricle and the aorta. Strophanthin caused a slight increase in cardiac index, and increases in heart rate, in dp/dt and peak gradient. The Starling curve was shifted upward to the left in five of seven patients. Pindolol had essentially the opposite effects. Neither drug influenced systolic aortic flow. Pindolol led to a significant reduction in the mixed venous oxygen saturation and an increase in arteriovenous oxygen difference. We conclude that strophanthin had no deleterious effect in the present study and that it may be of benefit in the individual patient by increasing the atrial contribution to ventricular filling and by improving the contractility of the septum and the left ventricular wall in advanced stages of the disease. Further controlled studies are necessary to define the effect of drug treatment in hypertrophic cardiomyopathy. Hypertrophic cardiomyopathy, digitalis, β-blockade, strophanthin, pindolol This content is only available as a PDF. Author notes Liv Storstein. Medical Department B. Rikshopitalet. Oslo. Norway © 1981, by The European Society Of Cardiology
TI - Hemodynamic effects of strophanthin and pindolol in patients with hypertrophic cardimyopathy
JF - European Heart Journal
DO - 10.1093/oxfordjournals.eurheartj.a061210
DA - 1981-08-01
UR - https://www.deepdyve.com/lp/oxford-university-press/hemodynamic-effects-of-strophanthin-and-pindolol-in-patients-with-TfMW4LDogB
SP - 297
EP - 305
VL - 2
IS - 4
DP - DeepDyve
ER -