TY - JOUR
AU - , DE KRETSER, D. M.
AB - We measured serum inhibin levels in eight untreated patients with prostatic cancer undergoing castration by RIA using an antiserum against 31-kDa bovine follicular fluid inhibin. The inhibin concentrations in testicular tissue and spermatic venous blood were also measured in six of these patients. Serum inhibin levels (mean ± sd, 377.8 ± 212.1 U/L), declined rapidly after castration (15 min after, 233 ± 171.4; 30 min, 224.6 ± 156.6; 1 h, 181.5 ± 95.9; 2 h, 174.3 ± 69.4; 4 h, 122 ± 6.4; 6 h, <120). High concentrations of inhibin were detected n i testicular tissue (31,360 ± 15,180 U/kg), and the levels in spermatic venous blood (3,178.3 ± 1,386.8 U/L) were approximately 10 times greater than those in peripheral blood (385.5 ± 233.1 U/L). Testosterone levels were 1,968.2 ± 992.3 nmol/kg in testicular tissue and approximately 100 times greater in spermatic venous blood (1,631.6 ± 389.7 nmol/L) than in peripheral blood (18.0 ± 4.4 nmol/L). These results suggest that circulating inhibin in men mainly originates from testis and that one of the routes of secretion is via the bloodstream. This content is only available as a PDF. Copyright © 1990 by The Endocrine Society
TI - Measurement of Inhibin Concentrations in Men: Study of Changes after Castration and Comparison with Androgen Levels in Testicular Tissue, Spermatic Venous Blood, and Peripheral Venous Blood
JF - Journal of Clinical Endocrinology and Metabolism
DO - 10.1210/jcem-70-4-1019
DA - 1990-04-01
UR - https://www.deepdyve.com/lp/oxford-university-press/measurement-of-inhibin-concentrations-in-men-study-of-changes-after-TM4tV5UI6c
SP - 1019
EP - 1022
VL - 70
IS - 4
DP - DeepDyve
ER -