TY - JOUR
AU - Damasceno, Alfredo
AB - Neurological Sciences https://doi.org/10.1007/s10072-023-06868-9 LE T TER TO  THE   EDITOR Pediatric onset primary progressive multiple sclerosis with predominant cognitive presentation: a longitudinal MRI and cognitive follow‑up 1 1 1 Gabriel de Deus Vieira  · Mariana Moreira Soares de Sá  · Ana Carolina Amaral de Andrade  · 1 1 Carla Renata Aparecida Vieira Stella  · Alfredo Damasceno Received: 19 April 2023 / Accepted: 17 May 2023 © Fondazione Società Italiana di Neurologia 2023 Introduction At the age of 23 years old, after a fainting episode, a brain MRI was requested, showing lesions suggestive of a demyeli- Primary Progressive Multiple Sclerosis (PPMS) occurs in nating disease, but without gadolinium enhancement. She was 10–15% of patients with MS, with a progressive evolution of referred to our MS center for investigation. The neurological symptoms, usually not having well-defined relapses, and often examination, except for the mental state, was unremarkable, and leading to a diagnosis delay by months or even years [1]. Most extensive etiological investigation was carried out, with negative cases start by age 40 with rare cognitive manifestations in serologies (i.e., neurosyphilis, HIV, and hepatitis), non-reactive their initial presentation. Among the clinical manifestations, rheumatological markers, normal vitamin B12 and, visual and spastic paraparesis is the most common (80%), followed by auditory evoked potentials. CSF analysis showed 0 leukocytes/ cerebellar ataxia (15%). In 
TI - Pediatric onset primary progressive multiple sclerosis with predominant cognitive presentation: a longitudinal MRI and cognitive follow-up
JF - Neurological Sciences
DO - 10.1007/s10072-023-06868-9
DA - 2023-10-01
UR - https://www.deepdyve.com/lp/springer-journals/pediatric-onset-primary-progressive-multiple-sclerosis-with-THXnKB0HyE
SP - 3731
EP - 3734
VL - 44
IS - 10
DP - DeepDyve
ER -