TY - JOUR
AU1 - Zimmermann, Bernhard B.
AU2 - Deng, Bin
AU3 - Singh, Bhawana
AU4 - Martino, Mark
AU5 - Selb, Juliette
AU6 - Fang, Qianqian
AU7 - Sajjadi, Amir Y.
AU8 - Cormier, Jayne
AU9 - Moore, Richard H.
AU1 - Kopans, Daniel B.
AU1 - Boas, David A.
AU1 - Saksena, Mansi A.
AU1 - Carp, Stefan A.
AU1 - 
AB - Abstract. Diffuse optical tomography (DOT) is emerging as a noninvasive functional imaging method for breast cancer diagnosis and neoadjuvant chemotherapy monitoring. In particular, the multimodal approach of combining DOT with x-ray digital breast tomosynthesis (DBT) is especially synergistic as DBT prior information can be used to enhance the DOT reconstruction. DOT, in turn, provides a functional information overlay onto the mammographic images, increasing sensitivity and specificity to cancer pathology. We describe a dynamic DOT apparatus designed for tight integration with commercial DBT scanners and providing a fast (up to 1 Hz) image acquisition rate to enable tracking hemodynamic changes induced by the mammographic breast compression. The system integrates 96 continuous-wave and 24 frequency-domain source locations as well as 32 continuous wave and 20 frequency-domain detection locations into low-profile plastic plates that can easily mate to the DBT compression paddle and x-ray detector cover, respectively. We demonstrate system performance using static and dynamic tissue-like phantoms as well as in vivo images acquired from the pool of patients recalled for breast biopsies at the Massachusetts General Hospital Breast Imaging Division.
TI - Multimodal breast cancer imaging using coregistered dynamic diffuse optical tomography and digital breast tomosynthesis
JF - Journal of Biomedical Optics
DO - 10.1117/1.JBO.22.4.046008
DA - 2017-04-01
UR - https://www.deepdyve.com/lp/spie/multimodal-breast-cancer-imaging-using-coregistered-dynamic-diffuse-SzjezE40p3
SP - 046008
EP - 046008
VL - 22
IS - 4
DP - DeepDyve
ER -