TY - JOUR
AU - Raikhel, N V
AB -  The directed movement of macromolecules into and out of the nucleus is a fundamental process in eukaryotes and occurs through the nuclear pore com­ plex (NPC). A diverse array of molecules are transported across the nuclear 1081-0706/95/1115-0155$05.00 HICKS & RAIKHEL envelope including proteins, mRNAs, tRNAs, snRNP complexes, ribosomal subunits, and in specialized cases, DNA. The structural and functional differ­ ences between these molecules point to the mechanistic complexity of NPCs and other components of the nuclear transport apparatus. This machinery must not only recognize within transported molecules specific targeting signals that differ between proteins, RNA, and RNNprotein complexes, it must translocate these molecules across the nuclear envelope. Additional levels of complexity are necessary becaus,e molecules such as proteins may continually undergo bidirectional transport across the envelope. Beyond these basic functions, the nuclear transport apparatus is regulated at the level of individual substrates and at more global levels such as coupling to cell cycle progression. INTRODUCTION In this review, we focus on protein import into the nucleus because, beyond their obvious biological importance, proteins are key factors in regulating all nuclear transport processes. For overviews of RNA and RNNprotein complex transport, readers may refer to a number of recent 
TI - Protein Import into the Nucleus: An Integrated View
JO - Annual Review of Cell and Developmental Biology
DO - 10.1146/annurev.cb.11.110195.001103
DA - 1995-11-01
UR - https://www.deepdyve.com/lp/annual-reviews/protein-import-into-the-nucleus-an-integrated-view-SyuxY1OSMc
SP - 155
EP - 188
VL - 11
IS - 1
DP - DeepDyve
ER -