TY - JOUR
AU1 - Köller, Manfred
AU2 - Hilger, Ralf A.
AU3 - Rihoux, Jean Pierre
AU4 - König, Wolfgang
AB - Leukotrienes are potent lipid mediators involved in acute and chronic inflammatory processes and allergic inflammation. Cetirizine is an H<sub>1</sub>-receptor antagonist used in the treatment of allergic symptoms. We analyzed the effect of cetirizine on the formation of leukotriene B<sub>4</sub> (LTB<sub>4</sub>) after stimulation of human peripheral blood neutrophils. The inflammatory mediators were analyzed after cellular activation with different stimuli: the Ca ionophore A23187, which bypasses membranous signal transduction elements; the bacterial peptide formyl-methionine-leucyl-phenylalonine (fMLP), which activates cells by binding to a GTP-protein (G-protein)-coupled receptor, and with sodium fluoride (NaF), which directly activates G-proteins. After cellular preincubation with cetirizine, the amounts of LTB<sub>4</sub> generated from neutrophil granulocytes decreased significantly when the cells were subsequently stimulated with either fMLP or NaF, in contrast to stimulations with the Ca ionophore. The data provide evidence that cetirizine exerts anti-inflammatory effects apart from H<sub>1</sub> antagonism.
TI - Cetirizine Exerts Anti-Inflammatory Effects on Human Neutrophils
JF - International Archives of Allergy and Immunology
DO - 10.1159/000237310
DA - 1996-01-01
UR - https://www.deepdyve.com/lp/karger/cetirizine-exerts-anti-inflammatory-effects-on-human-neutrophils-Swdrv0snXr
SP - 52
EP - 56
VL - 110
IS - 1
DP - DeepDyve
ER -