TY - JOUR
AU1 - FORD, C. E.
AB - MOSAICS AND CHIMAERAS C. E. Ford can reasonably be attributed to chance (Court-Brown, Jacobs & Doll, 1960). Unfortunately this criterion cannot be applied with rigour. It is true that the probabilities of obtaining given sets of observations by chance can be calculated by use of the binomial distribution; it is the assumptions involved that are open to question, as the following hypothetical example illustrates. Suppose a sample of 20 cells from a child with Down's C. E. FORD D.Sc. F.R.S. syndrome consists of 17 cells with a count of 47 chromosomes including 5 of group G, and 3 cells with 46 chromosomes, 2 of Medical Research Council them with 4 in group G, and 1 with 5 in group G but lacking Radiobiological Research Unit a chromosome from one of the other groups. If hypomodal Harwell, Didcot, Berkshire cells originate by random losses of chromosomes (whether through mitotic error or preparative artifact is immaterial), 1 Diagnosis of mosaics the probability that the observed group of hypomodal cells 2 Sex-chromosome mosaics originated by chance independent events is given by the sum 3 Autosome mosaics of the last two terms of the binomial expansion (42/47+ 5/47)3. 4 Mosaic monozygotic twins 5 
TI - MOSAICS AND CHIMAERAS
JF - British Medical Bulletin
DO - 10.1093/oxfordjournals.bmb.a070658
DA - 1969-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/mosaics-and-chimaeras-SrVqKxMWH0
SP - 104
EP - 109
VL - 25
IS - 1
DP - DeepDyve
ER -