TY - JOUR AU1 - Podlasek, Stanley, J. AU2 - McPherson, Richard, A. AB - Abstract We report the case of a 67-year-old man who developed an autoantibody against lactate dehydrogenase (LD) in association with an episode of pericarditis following soon after myocardial infarction and streptokinase treatment. This anti-LD was shown to he an IgM antibody. The alteration in LD isoenzyme electrophoretic pattern caused by this IgM anti-LD was modified by treatment with dithiothreitol. The molecular size of the LD-antibody complex established by gel filtration was consistent with an LD-IgM interaction. This temporal association of an IgM anti-LD primary immune response after streptokinase infusion suggests that streptokinase may play an etiologic role in stimulating formation of anti-LD antibodies. This content is only available as a PDF. © American Society of Clinical Pathologists TI - New Lactate Dehydrogenase–IgM Complexes JF - Laboratory Medicine DO - 10.1093/labmed/20.9.617 DA - 1989-09-01 UR - https://www.deepdyve.com/lp/oxford-university-press/new-lactate-dehydrogenase-igm-complexes-Sn8mmOYDa7 SP - 617 EP - 619 VL - 20 IS - 9 DP - DeepDyve ER -