TY - JOUR
AU1 - Sherr, David H.
AU2 - Cheung, Nai-Kong V.
AU3 - Heghinian, Krikor M.
AU4 - Benacerraf, Baruj
AU5 - Dorf, Martin E.
AU6 - 
AB - <jats:title>Abstract</jats:title>
               <jats:p>Intravenous administration of syngeneic spleen cells coupled with the palmitoyl derivative of fowl γ-globulin (p-FγG) results in a profound state of FγG-specific tolerance in C57BL/6 mice. Administration of p-FγG coupled syngeneic cells specifically reduces both the primary and secondary hapten and carrier-specific PFC responses to TNP-FγG. Since the haptenic response is affected, the tolerance functions at the level of the FγG-specific helper T cell. As few as 103 p-FγG spleen cells carrying only 1 ng of p-FγG can induce tolerance. At least a 2-day-induction period is required. This nonresponsiveness is long lived, lasting over 120 days. Spleen cells from tolerized mice can transfer suppression to normal syngeneic recipients. Treatment of tolerant spleens with anti-Thy 1.2 antiserum + C eliminates the suppressor cell activity. In addition, thymocytes and purified splenic T cells from tolerized mice can transfer suppression to normal recipients. Thus, at least a component of this nonresponsiveness is mediated by suppressor T cells. The requirement of antigen association with cell membrane components and the general applicability of this method of inducing T cell nonresponsiveness are discussed.</jats:p>
TI - Immune Suppression <i>in vivo</i> with Antigen-Modified Syngeneic Cells
JF - The Journal of Immunology
DO - 10.4049/jimmunol.122.5.1899
DA - 1979-05-01
UR - https://www.deepdyve.com/lp/crossref/immune-suppression-i-in-vivo-i-with-antigen-modified-syngeneic-cells-Sd4w00CAr5
SP - 1899
EP - 1904
VL - 122
IS - 5
DP - DeepDyve
ER -