TY - JOUR
AU1 - Gurwith, Marc J.
AU2 - Langston, Claire
AU3 - Citron, Diane M.
AB - Abstract • After finding enterotoxigenic (ET) Escherichia coli in two consecutive cases of sudden infant death syndrome (SIDS), we initiated a prospective search for ET E coli in SIDS in Manitoba; in addition, we looked for toxigenic Clostridium botulinum and C difficile. In a 21-month period, small- and large-bowel contents were obtained in 33 cases of SIDS, from 32 control subjects, and in ten suspected cases of SIDS. Neither C botulinum nor ET E coli was isolated from any of these; C difficile was cultured from postmortem bowel contents of two SIDS and seven control cases. The overall isolation rate of C difficile was 17%. Despite the fact that two of these cases had toxin detectable in the bowel contents, no evidence of colitis was found in any of the cases with C difficile. We conclude that C botulinum or ET E coli have only a small role, if any, in the etiology of SIDS, and that C difficile is found relatively commonly in the gastrointestinal tract of infants without apparent local or systemic effects. (Am J Dis Child 1981;135:1104-1106) References 1. Langston C: Sudden infant death syndrome . Hum Pathol 1976;7:492-494.Crossref 2. Arnon SS, Damus K, Midura TF, et al: Intestinal infection and toxin production by Clostridium botulinum as one cause of sudden infant death syndrome . Lancet 1978;1:1273-1276.Crossref 3. Brunton J, Hinde D, Langston C, et al: Enterotoxigenic Escherichia coli in central Canada . J Clin Microbiol 1980;11:343-347. 4. Gurwith MJ: Rapid screening method for enterotoxigenic Escherichia coli . J Clin Microbiol 1977;6:314-316. 5. Gurwith MJ, Williams TW: Gastroenteritis in children: A two year review in Manitoba . J Infect Dis 1977;136:239-247.Crossref 6. Sütter VL, Citron DM, Finegold SM: Wadsworth Anaerobic Bacteriology Manual , ed 3. St Louis, CV Mosby Co, 1980. 7. George WL, Sütter VL, Citron D, et al: Selective and differential medium for isolation of Clostridium difficile . J Clin Microbiol 1979;9:214-219. 8. Rolfe RD, Finegold SM: Purification and characterization of Clostridium difficile toxin . Infect Immun 1979;25:191-201. 9. Cumberbatch N, Gurwith MJ, Langston C, et al: Cytotoxic enterotoxin produced by Aeromonas hydrophila: Relationship of toxigenic isolates to diarrheal disease . Infect Immun 1979;23:829-837. 10. Field M: Modes of action of enterotoxins from Vibrio cholerae and Escherichia coli . Rev Infect Dis 1979;1:918-925.Crossref 11. Deetz TR, Evans DJ Jr, Evans EG, et al: Serologic responses to somatic O and colonization-factor antigens of enterotoxigenic Escherichia coli in travelers . J Infect Dis 1979;140:114-118.Crossref 12. Elomaa E: Enterotoxins of Escherichia coli and epilepsy . Med Hypotheses 1979;5:707-710.Crossref 13. Scopes JW, Smith MF, Beach RC: Pseudomembranous colitis and sudden infant death . Lancet 1980;1:1144.Crossref 14. Snyder ML: Normal fecal flora of infants between 2 weeks and 1 year of age . J Infect Dis 1940;66:1-12.Crossref 15. Rietra PJGM, Slaterus KW, Zanen HC, et al: Clostridial toxin in faeces of healthy infants . Lancet 1978;2:319.Crossref 16. Arnon SS: Infant botulism . Ann Rev Med 1980;31:541-560.Crossref 17. Moberg LJ, Sugiyama H: The rat as an animal model for infant botulism . Infect Immun 1980;29:819-821.
TI - Toxin-Producing Bacteria in Infants: Lack of an Association With Sudden Infant Death Syndrome
JF - American Journal of Diseases of Children
DO - 10.1001/archpedi.1981.02130360012006
DA - 1981-12-01
UR - https://www.deepdyve.com/lp/american-medical-association/toxin-producing-bacteria-in-infants-lack-of-an-association-with-sudden-STcWvmi0Jl
SP - 1104
EP - 1106
VL - 135
IS - 12
DP - DeepDyve
ER -