TY - JOUR
AU - Nakamura, Yuki
AB - Cationic cyclophane pentamer 1 has been prepared from a tetraazide-functionalized cyclophane derivative and four acetylene-functionalized cyclophane derivatives by Cu(I)-catalyzed 1,3-dipolar cycloadditions (click chemistry) in a 87% yield, followed by a treatment with trifluoroacetic acid. Cationic host 1 showed effective guest-binding behavior toward fluorescent guests such as 6-p-toluidinonaphthalene-2-sulfonate, in comparison with those of monomeric cyclophane. On the other hand, anionic cyclophane pentamer 2, which was derived from 1 by a reaction with succinic anhydride, showed enhanced guest-binding affinity toward anticancer drugs such as daunorubicin hydrochloride, in comparison with those of the monomeric cyclophane.
TI - Synthesis of Water-Soluble Cyclophane Pentamers Using Click Chemistry as a Multivalent Host for Daunorubicin and Doxorubicin
JF - Bulletin of the Chemical Society of Japan
DO - 10.1246/bcsj.20120296
DA - 2013-02-02
UR - https://www.deepdyve.com/lp/oxford-university-press/synthesis-of-water-soluble-cyclophane-pentamers-using-click-chemistry-SSihpUMxD0
SP - 223
EP - 229
VL - 86
IS - 2
DP - DeepDyve
ER -