TY - JOUR
AU - Luft, F.C.
AB - J Mol Med (1999) 77:656–665 © Springer-Verlag 1999 Digital Object Identifier (DOI) 10.1007/s001099900050 REVIEW Geert J.P.L. Kops · Boudewijn M.T. Burgering Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling Received: 19 July 1999 / Accepted: 6 September 1999 / Published online: 23 September 1999 Abstract The proto-oncogene protein kinase B (PKB), activities of certain viruses, and the negative regulator of also known as c-Akt, is a central player in a signaling this pathway, PTEN, is a tumor suppressor. The identifi- pathway of which many components have been linked to cation of particular downstream targets of PKB has pro- tumorigenesis. Active forms of PKB as well as of its up- vided us with new insights into the possible mechanism stream activator phosphatidylinositol 3-kinase (PI3K) of PI3K/PKB-mediated tumorigenicity. Recently a sub- have been found to be responsible for the transforming family of Forkhead transcription factors was identified as additional targets for PI3K/PKB signaling. This re- view discusses the studies that have led to this conclu- sion and the possible implications of this finding for our understanding of how PI3K/PKB activity could lead to oncogenesis. Key words Proto-oncogene · Protein kinase B · Transcription · Forkheads · Tumor suppression 
TI - A light, rather than a heavy solution for hard working hearts
JF - Journal of Molecular Medicine
DO - 10.1007/s001099900037
DA - 1999-09-23
UR - https://www.deepdyve.com/lp/springer-journals/a-light-rather-than-a-heavy-solution-for-hard-working-hearts-SNys6nqaTI
SP - 631
EP - 633
VL - 77
IS - 9
DP - DeepDyve
ER -