TY - JOUR AU1 - Rodrigues-Neto, Jorge AU2 - Correia, Mauro AU3 - Souto, Augusto AU4 - Ribeiro, José AU5 - Vieira, Letícia AU6 - Souza, Manoel AU7 - Rodrigues, Clenilson AU8 - Abdelnur, Patrícia AB - Introduction Oil palm (E. guineensis), the most consumed vegetable oil in the world, is affected by fatal yellowing (FY), a condition that can lead to the plant’s death. Although studies have been performed since the 1980s, including investigations of biotic and abiotic factors, FY’s cause remains unknown and efforts in researches are still necessary. Objectives This work aims to investigate the metabolic expression in plants affected by FY using an untargeted metabo- lomics approach. Method Metabolic fingerprinting analysis of oil palm leaves was performed using ultra high liquid chromatography–elec- trospray ionization–mass spectrometry (UHPLC–ESI–MS). Chemometric analysis, using principal component analysis (PCA) and partial least square discriminant analysis (PLS-DA), was applied to data analysis. Metabolites identification was performed by high resolution mass spectrometry (HRMS), MS/MS experiments and comparison with databases and literature. Results Metabolomics analysis based on MS detected more than 50 metabolites in oil palm leaf samples. PCA and PLS-DS analysis provided group segregation and classification of symptomatic and non-symptomatic FY samples, with a great exter - nal validation of the results. Nine differentially expressed metabolites were identified as glycerophosphorylcholine, arginine, asparagine, apigenin 6,8-di-C-hexose, tyramine, chlorophyllide, 1,2-dihexanoyl-sn-glycero-3-phosphoethanolamine, proline and malvidin 3-glucoside-5-(6″-malonylglucoside). Metabolic pathways and biological importance of those metabolites were TI - Metabolic fingerprinting analysis of oil palm reveals a set of differentially expressed metabolites in fatal yellowing symptomatic and non-symptomatic plants JF - Metabolomics DO - 10.1007/s11306-018-1436-7 DA - 2018-10-11 UR - https://www.deepdyve.com/lp/springer-journals/metabolic-fingerprinting-analysis-of-oil-palm-reveals-a-set-of-SJCEVlewx7 SP - 1 EP - 16 VL - 14 IS - 10 DP - DeepDyve ER -