TY - JOUR AU1 - Bedrač, Leon AU2 - Deutsch, Leon AU3 - Terzić, Sanja AU4 - Červek, Matej AU5 - Šelb, Julij AU6 - Ašič, Urška AU7 - Verstraeten, Laure M. G. AU8 - Kuščer, Enej AU9 - Cvetko, Filip AB - Background: Endurance athletes require tailored nutrition strategies to optimize performance, recovery, and training adaptations. While traditional sports nutrition guidelines provide a foundational framework, individual variability in metabolic responses underscores the need for precision nutrition, informed by genetic, biological, and environmental factors. This scoping review evaluates the application of systems biology-driven sports nutrition for endurance athletes, focusing on ‘omics’ and wearable technologies. Methods: A scoping review of the literature was conducted in PubMed, Scopus, and Web of Science in accordance with the PRISMA-ScR checklist. Research questions, search strategies, and eligibility criteria were guided by the Population–Concept–Context framework with the following inclusion criteria: original research in English, involving endurance athletes, systems biology approaches, and nutritional interventions or continuous glucose monitoring (CGM). Results: Fifty-two studies were included, with distance runners as the most studied cohort. Eleven studies used metagenomics, eleven CGM, ten nutrigenetics, ten metabolomics, seven multi-omics, one proteomics, one epigenomics, and one lipidomics. Over half (n = 31; 60%) were randomized controlled trials (RCTs) with generally high methodological quality. Conclusions: Most studies were proof-of-concept investigations aimed at assessing biomarkers; however, the evidence linking these biomarkers to performance, recovery, and long-term health outcomes in endurance athletes remains insufficient. Future research should focus on well-powered replicated crossover RCTs, multivariate N-of-1 clinical trials, 360-degree systems-wide approaches, and the validation of genetic impacts on nutritional interventions to refine dietary guidelines. TI - Towards Precision Sports Nutrition for Endurance Athletes: A Scoping Review of Application of Omics and Wearables Technologies JF - Nutrients DO - 10.3390/nu16223943 DA - 2024-11-19 UR - https://www.deepdyve.com/lp/multidisciplinary-digital-publishing-institute/towards-precision-sports-nutrition-for-endurance-athletes-a-scoping-SER0jwcAkL SP - 3943 VL - 16 IS - 22 DP - DeepDyve ER -