TY - JOUR
AU - Seibert, Florence B.
AB - THE SIGNIFICANCE OF ANTIGEN-ANTIBODY REACTIONS IN TUBERCULOSIS FLORENCE B. SEIBERT From the Henry Phipps Institute, University of Pennsylvania, Philadelphia, Pennsylvania Potent antigens, such as the tubercu­ cells recognized to be antibody produc­ loprotein and tuberculopolysaccharide ers,2-1i and, moreover, of accelerating could conceivably be present in tubercu­ the development of caseation and hast­ lous tissues containing disintegrating ening death in infected animals" has tubercle bacilli. And if, perchance, anti­ been demonstrated. In addition to the body-producing cells, which are at­ tuberculoprotein, recent studies! sug­ tracted to the site, release their anti­ gest that the tuberculopolysaccharide bodies, the sim ultaneous presence of may also play an important role in the antigen and antibody could be expected disease because of its capability of sup­ to give rise to a precipitate in situ, simi­ pressing immunological reactions, such lar to that formed when the two are as the complement-fixation and precipi­ mixed in vitro. Because of the accom­ tin reactions. panying cellular reaction to such a pre­ PLAN OF EXPERIMENTS cipitate, it would become fixed locally. Furthermore, when the bacillary popu­ In order to test the hypothesis set lation would increase sufficiently to per­ forth above, concerning the im portance mit the presence 
TI - The Significance of Antigen-antibody Reactions in Tuberculosis
JO - The Journal of Infectious Diseases
DO - 10.1093/infdis/99.1.76
DA - 1956-07-01
UR - https://www.deepdyve.com/lp/oxford-university-press/the-significance-of-antigen-antibody-reactions-in-tuberculosis-S7iVbHA1ZW
SP - 76
EP - 83
VL - 99
IS - 1
DP - DeepDyve
ER -