TY - JOUR
AU - Fu, Lung-Ming
AB - A novel three-dimensional (3D) disposable glucose concentration detection chip is presented. The chip comprises a four-layer polymethyl methacrylate (PMMA) structure and is fabricated using a commercial CO2 laser and a hot-press bonding technique. In the proposed device, the glucose solution is injected into a double parallel connection micromixer (DPCM) and is mixed with DNS reagent by means of a self-rotation effect. An experimental platform has been created for multiple reaction process by integrating chip and micro-heater. The fluid streams exiting the two circular mixing chambers of the DPCM are then combined and mixed further at a T-type microchannel outlet before passing to a collection chamber. Numerical simulations are performed to analyze the vortex streamline distribution within the DPCM and to estimate the mixing performance. The numerical results show that a mixing efficiency as high as 92.5% can be obtained at low Reynolds numbers (Re = 12). It is found a good linear relation of R
2 = 0.9953 from the chip detection method comparing to the traditional method of R
2 = 0.9976 at DNS reagent and glucose solution volume ratio of 1:1. In addition, the experimental results show that the accuracy of the glucose concentration measurements obtained using the proposed microfluidic chip is comparable with that of the measurements obtained using a conventional large-scale detection method. Overall, the results presented in this study indicate that the DPCM chip provides a rapid and low-cost means of detecting the concentration of glucose solutions.
TI - Rapid glucose concentration detection utilizing disposable integrated microfluidic chip
JF - Microfluids and Nanofluids
DO - 10.1007/s10404-011-0813-6
DA - 2011-05-12
UR - https://www.deepdyve.com/lp/springer-journals/rapid-glucose-concentration-detection-utilizing-disposable-integrated-ReTPYx66OW
SP - 479
EP - 487
VL - 11
IS - 4
DP - DeepDyve
ER -