TY - JOUR
AU - Soulier, J.P.
AB - From January 1980 to December 1983, 989,907 blood donations were screenedfor HBsAg. A total of 1,345 was found HBsAg positive; 33 of whom were negative foranti-HBc (2.45%); in 10 cases HBeAg was present at a low level along with HBsAg. 2 of the 33subjects were lost to follow-up. Late serum samples were available for 28 blood donors, andclinical and biological data only were known for the 3 others. An evolution of HBV markerswas observed in each case; anti-HBc antibody became positive in 24 subjects (the 4 remainingsubjects had a very short follow-up) ; HBeAg was positive at a high titer in 18 subjects andseroconversion to anti-HBe was observed in 7 individuals; HBsAg concentration increasedin 21 subjects from 2 to 4,000 times and decreased in the 7 others. Seroconversion toanti-HBs was observed in 8 individuals. According to these serological, biological andclinical findings, different outcomes were observed: in 6 subjects too short a follow-up wasavailable to allow appropriate classification, but there was evidence to suggest all probablydeveloped clinical hepatitis; in 6 subjects asymptomatic hepatitis with rapid loss of HBsAgoccurred; in 2 subjects asymptomatic hepatitis with the persistence of HBsAg at a low leveland seroconversion to anti-HBe occurred; and in 17 subjects clinical hepatitis developed.These observations establish that most of the 33 blood donors were infectious at the time oftheir blood donation, and that anti-HBc antibody screening must not replace HBsAgscreening for blood donations.
TI - Blood Donors Positive for HBsAg and Negative for Anti-HBc Antibody
JF - Vox Sanguinis
DO - 10.1159/000466343
DA - 2017-01-01
UR - https://www.deepdyve.com/lp/karger/blood-donors-positive-for-hbsag-and-negative-for-anti-hbc-antibody-Re2dnCvLZ7
SP - 26
EP - 33
VL - 49
IS - 1
DP - DeepDyve
ER -