TY - JOUR
AU - Griffin, G E
AB - Abstract Adverse reactions are seen relatively frequently after treatment of onchocerciasis patients with ivermectin. The chemokines RANTES and IL-8, which have both chemotactic and activation properties for eosinophils and neutrophils, respectively, may have a role in the pathogenesis of post-treatment reactions. Circulating levels of the chemokines and the cytokines tumour necrosis factor-alpha (TNF-α) and IL-6 were measured in the plasma of 22 Onchocerca volvulus-infected subjects. Peaks of mean circulating levels of RANTES and TNF-α were seen at 6 h after ivermectin administration. Peripheral eosinophil counts declined at 36 h post-treatment and an early peak in RANTES levels was associated with a delay in peripheral eosinopenia. RANTES levels were negatively correlated with severity of rash (P < 0.001) and lymphoedema (P < 0.05), suggesting that high circulating levels of RANTES may inhibit eosinophil sequestration. No changes in circulating levels of IL-8 were seen. These findings suggest a possible role of circulating RANTES in modulating eosinophil sequestration in vivo. onchocerciasis, ivermectin, chemokines, RANTES, cytokines This content is only available as a PDF. © 1996 Blackwell Science Ltd This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
TI - RANTES in onchocerciasis: changes with ivermectin treatment
JO - Clinical & Experimental Immunology
DO - 10.1046/j.1365-2249.1996.d01-868.x
DA - 2003-10-29
UR - https://www.deepdyve.com/lp/oxford-university-press/rantes-in-onchocerciasis-changes-with-ivermectin-treatment-RLobhQDoG9
SP - 462
EP - 467
VL - 106
IS - 3
DP - DeepDyve
ER -