TY - JOUR
AU - PLAYFAIR, J H L
AB - British Medical Bulletin (1982) Vol. 38, No. 2, pp. 153-159 IMMUNITY TO MALARIA JHLPlayfair The comparative resistance of newborn mice and humans up to 4—6 months can be traced to a lack of p-aminobenzoic acid in milk, this being an essential factor in the synthesis by the parasite of tetrahydrofolate and thence thymidine (Hawking, 1954). In most cases, of course, milk will contain protective antibodies too (see section 7). Tosta & Filho (1977) found a non-antibody factor in adult rat serum which partially pro- J H L PLAYFAIR PhD MB BChir tected newborn rats against Plasmodium berghei. The natural resistance of a particular host to a particular Middlesex Hospital, London parasite can sometimes be located to the spleen. For example, P. falciparum will infect splenectomized but not intact gibbons and marmosets (Morris et al. 1966). The role of the spleen in 1 Evidence for immunity in malaria immunity is discussed further in section 6. a Natural immunity _ b Acquired immunity: specific b Acquired Immunity: Specific c Acquired immunity: non-specific 2 Changes in the immune system The period of greatest risk in human malaria is from six a Humoral responses months to five years, after which the disease becomes 
TI - IMMUNITY TO MALARIA
JF - British Medical Bulletin
DO - 10.1093/oxfordjournals.bmb.a071752
DA - 1982-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/immunity-to-malaria-RGKtou1WD7
SP - 153
EP - 160
VL - 38
IS - 2
DP - DeepDyve
ER -